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Health & Physiology

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RAINmakers: how receptors orchestrate specific cell functions

 All physiological functions in humans are orchestrated by cell surface receptors and their intracellular signaling effects. Cell signaling typically consists of 5 components: stimulus, receptor, transducer, messenger, and effector. These components are modularly linked to each other to ensure that extracellular cues are relayed flawlessly... click to read more

  • Charlotte Kayser | Postdoctoral Research Fellow at Max Delbrück Center for Molecular Medicine
  • Andreas Bock | Professor at Leipzig University
Views 206
Reading time 4 min
published on Feb 2, 2023
How do immune cells enter tissues to protect the body?

Most cells in our body don’t move: they stay put, forming dense tissues. But one population of cells moves continually, and we would not survive without them. These immune cells arrive at any spot in our body where damage or infection arises. Immune cells... click to read more

Views 488
Reading time 3.5 min
published on Jan 17, 2023
Child masking prevents childcare closure during the COVID-19 pandemic

Over the last two years, multiple risk mitigation strategies have been deployed to reduce the rate of spread of SARS-CoV-2 (the virus that causes COVID-19) in congregate settings, including schools and early childcare programs. Layered strategies include: screening for COVID-19 related symptoms and/or SARS-CoV-2 testing... click to read more

  • Thomas S. Murray | Associate Professor at Yale University School of Medicine, New Haven, Connecticut, USA
  • Amyn A. Malik | Postdoctoral Research Fellow at Yale Institute for Global Health, New Haven, Connecticut, USA
  • Walter S. Gilliam | Professor at Yale Child Study Center, New Haven, Connecticut, USA
Views 371
Reading time 4 min
published on Dec 26, 2022
The needle-free detection of SARS-CoV-2-specific antibodies from urine

While serological tests are not intended to diagnose an acute SARS-CoV-2 (COVID-19) infection, they can indicate the presence of antibodies generated from previous viral exposure or vaccination. Several diagnostic kits to assess the presence of SARS-CoV-2 antibodies are available on the market, all using blood/serum... click to read more

  • Fernanda Fonseca Ramos | Junior Postdoctoral Research Fellow at Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • Eduardo Antônio Ferraz Coelho | Full Professor at Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • Fernanda Ludolf | Senior Postdoctoral Research Fellow at Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Views 312
Reading time 3 min
published on Dec 22, 2022
Floppy proteins and the hidden sequences they use to communicate

When the first protein structure was solved in 1958, scientists knew they had broken into a new frontier of biology. They felt that a protein’s structure would reveal all the secrets of its function, and almost 70 years down the line, over 150,000 structures have... click to read more

  • Theresa Hwang | PhD Student at Massachusetts Institute of Technology, USA
  • Amy Keating | Professor at Massachusetts Institute of Technology, USA
Views 919
Reading time 4 min
published on Oct 11, 2022