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epigenetics

number of breaks: 6

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Keeping the balance: How epigenetics monitors cancer genes

The human genome contains around 20,000 genes with two copies per gene, one inherited from each parent. Changes in the genome including gene breaks, rearrangements, and extra gene copies are frequent in many diseases, most commonly in cancer. DNA breaks occur often throughout the genome,... click to read more

  • Zach Gray | PhD student at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA 19111; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia PA 19111
  • Madison Honer | PhD student at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA 19111; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia PA 19111
  • Johnathan Whetstine | Professor at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111
Views 1047
Reading time 4 min
published on May 13, 2024
Writing cell memory: how Histones play a role in Epigenetic Memory

Expression of a correct set of genes at the right time is crucial for cells to maintain their cell-type specific function. Epigenetic cell memory supports maintenance of such gene expression programs, with specific chromatin states regulating which genes to express or to keep silent. Chromatin... click to read more

  • Valentin Flury | Postdoctoral Research Fellow at University of Copenhagen
  • Anja Groth | Professor at University of Copenhagen
Views 1259
Reading time 4 min
published on Oct 4, 2023
Stressful memories help plants resist caterpillars

Global yields of major food crops, such as rice and wheat, are estimated to be reduced by one fifth due to damage from pests and diseases. Chemical pesticides are currently the primary control strategy in agriculture. Unfortunately, these chemicals can be harmful to human health... click to read more

Views 1450
Reading time 3.5 min
published on Oct 2, 2023
Age-induced unsealing of the "Pandora's box": resurrection of endogenous retroviruses

Human evolution is like a tightrope walker with viruses – in a delicate balance. Endogenous retroviruses (ERVs), once part of ancient retroviral infections, are now permanently fixed in our genome. Most of them, including human ERVs (HERVs), like landmines buried in the past, accumulate mutations... click to read more

Views 781
Reading time 3.5 min
published on Sep 20, 2023
How behavior can transcend generations

The brain is a specialized organ that interprets information about the surroundings and translates it into behavior, allowing animals to cope with their dynamic environments. Ever since antiquity, thinkers (and helpless parents) have suggested that the activity of one's brain could somehow impact the fate... click to read more

  • Itai Antoine Toker | PhD student at Department of Neurobiology, Wise Faculty of Life Sciences, Tel Aviv University, Israel
Views 6559
Reading time 3.5 min
published on Dec 10, 2019