/
partner with:

histones

number of breaks: 3

showing 1-3 of 3 breaks

Keeping the balance: How epigenetics monitors cancer genes

The human genome contains around 20,000 genes with two copies per gene, one inherited from each parent. Changes in the genome including gene breaks, rearrangements, and extra gene copies are frequent in many diseases, most commonly in cancer. DNA breaks occur often throughout the genome,... click to read more

  • Zach Gray | PhD student at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA 19111; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia PA 19111
  • Madison Honer | PhD student at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA 19111; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia PA 19111
  • Johnathan Whetstine | Professor at Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA 19111
Views 775
Reading time 4 min
published on May 13, 2024
Writing cell memory: how Histones play a role in Epigenetic Memory

Expression of a correct set of genes at the right time is crucial for cells to maintain their cell-type specific function. Epigenetic cell memory supports maintenance of such gene expression programs, with specific chromatin states regulating which genes to express or to keep silent. Chromatin... click to read more

  • Valentin Flury | Postdoctoral Research Fellow at University of Copenhagen
  • Anja Groth | Professor at University of Copenhagen
Views 1159
Reading time 4 min
published on Oct 4, 2023
More than meets the eye: the histones revealed as enzymes

If you traveled back in time to approximately two billion years ago, you would see an Earth completely devoid of animals and plants. Yet, at microscopic levels, life is on the brink of one of the greatest and unique developments in history. Two single celled... click to read more

  • Oscar A. Campos | Postdoctoral scholar at Department of Biological Chemistry at the David Geffen School of Medicine, University of California, Los Angeles
  • Siavash K. Kurdistani | Professor at Department of Biological Chemistry at the David Geffen School of Medicine, University of California, Los Angeles
Views 3990
Reading time 3 min
published on Jan 12, 2021