Discovery of high-order drug synergies – from impossible to dirt cheap
By combining two or more drugs together (synergistic drug approach) it is possible to obtain a greater effect than with an individual drug alone. For example, the treatment of many diseases, ranging from cancer to tuberculosis to chronic diseases, depends on the use of three... click to read more
Killing C. difficile with targeted strikes
Clostridium difficile is a bacterium that causes hundreds of thousands of antibiotic-associated diarrhoea cases every year, and these infections often prove fatal. Usually, C. difficile is unable to cause disease as the bacterium is kept in check by the friendly bacteria in the gut; the... click to read more
Studies of the bugs within: telling sickness from cure
Each of us carries intestinal gardens, where microbes process food for our own consumption. We evolved to benefit from this, but as our guests are selfish single-cell creatures, tense diplomacy was always needed. Since these bacterial communities in our gut play surprisingly large roles in... click to read more
Gut microbes as a novel anti-aging intervention?
Ours is a world dominated by microbes. Diverse microbial communities colonize just about any available space, even deep within our bodies' cavities. Remarkably, every human being carries as many bacterial as human cells, leading us to question the very meaning of what constitutes a human.... click to read more