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53 articles
We developed a new neural probe which can be inserted into the deep vasculature of the brain to achieve high-precision measurement of its activity. This...
The brain's immune system helps us defend ourselves against pathogens and attacks, but what happens when it doesn't or it overreacts? Could it be dangerous?...
Social behavior and communication are key to building relationships in most species. Vasopressin, a neurochemical commonly known for regulating blood pressure...
We all pursue goals. These goals motivate some of our behaviors which allow us to interact with the environment until we satisfy our needs and desires. We...
What is going on with SARS-CoV-2 infection and your brain? Even in mild infection there may be neurological injury that affects recovery. In our study, brain...
Amyotrophic lateral sclerosis and frontotemporal dementia are devastating neurological diseases. Yet, there is no effective treatment for them. We uncovered a...
Schizophrenia is widely thought to involve the disruption of both early and late phases of brain development – the so-called ‘two-hit’ hypothesis – but what is...
The gut-brain pathway has been the center of many studies in the past few years, but the mechanisms driving this interaction are still poorly understood. In...
The neurons of the eye that detect light must be very sensitive. They also need a lot of energy, so they contain many mitochondria - however, mitochondria...
In a recent study, we investigated a crucial brain blood flow regulation mechanism in mouse models of heart disease and dementia. We found that there was a...
The SARS-CoV-2 virus rarely infects olfactory sensory neurons yet causes widespread anosmia. To explain this apparent paradox, we found that odour detection is...
Alzheimer’s disease leads to progressive dementia, profound disability and impaired quality of life. Globally, there are more than 50 million cases, over two...
Confidence and uncertainty in our thoughts are extremely important when making decisions, but how does the brain compute confidence? We found a region in the...
Eating when hungry, drinking when thirsty and fear under threat are essential behaviors for animal survival produced by the long evolution of life. We found...
Like us, monogamous prairie voles can form lifelong pair bonds. We asked how these long-term bonds change brain activity in brain regions associated with...
For most neurological disorders, age means more damage and worse clinical outcomes. Using advanced techniques, we determined what it is about the aging central...
When you and your friends reminisce about your last year of high school, the memories are characterized by your perspective and experience making them unique....
Vision is considered among our most valuable senses. For many, it is taken for granted. Tackling the challenge facing visually impaired individuals may now be...
Updating learning to control our actions is a fundamental aspect of brain function. It eliminates behaviours that use valuable energy for no reward. Here, we...
Why is holding hands enjoyable but stubbing fingers painful? Our body judges whether a physical force is “dangerous” depending on its intensity to decide if it...
Until recently, the immune system was thought to be excluded from the brain. A new study shows that the immune system is not only able to enter the brain - it...
Why are we all different? By comparing brain anatomy we uncovered anatomical difference in the brain of individuals, resulting from chance processes during...
Individual variations in our genetic material contribute to more than we imagined and may combine with age and sex to influence how someone responds to drugs...
Limited sleep causes many health problems, and it can eventually lead to death in some extreme cases. Why is sleep essential for life? We found that sleep...
The congenital Zika syndrome is a set of birth disabilities caused by Zika virus infection during gestation. However, not all infected mothers transmit the...
We discovered in rats the long-sought brain circuit mechanism of "mind–body connection". This mechanism is critical for driving a variety of autonomic and...
An immune response is the body’s way of limiting damage and paving the way for repair. Specialized cells kill harmful invaders, clean up damaged tissue, and...
Sleep loss perturbs the molecular circadian clock inside our cells. This effect persists long after the organism has recovered from sleep loss at the...
Microglia, the immune cells of the brain, helps the brain modify its circuits in response to new experiences. In a recent study, we found that microglia...
The latest neurobiological research is revealing important and influential neural pathways between the brain to organ systems, indicating the potential power...
By comparing the genetic sequence of right-handers versus left-handers, we have uncovered regions in the genome that are linked to an increased chance of being...
What happens when visually responsive neurons in the primate brain are allowed to interact with artificial neural networks that generate images?
What neuroscience has found about the brains of “selfish” and “selfless” people? To understand what is really driving our behaviour, scientists need to look...
The continuous generation of new neurons during lifetime is crucial for learning and memory. In humans, we found a mild decrease in the number of these...
One out of every two patients with Parkinson's disease (PD) experience anxiety and depressive symptoms. Our study unraveled that mindfulness yoga that teaches...
The human brain contains clusters of neurons in the visual cortex that help us recognize important objects, like faces and words. Surprisingly, these regions...
All animals sleep, and the loss of sleep result in significant deficits to brain performance. Prolonging sleep deprivation could be fatal; however, why do we...
Brain activity emerges from the coordinated dynamics of a huge network of neurons. Here, we explored what sorts of wave patterns can arise at the whole-brain...
Behavioral assessments in animal models are crucial to neuroscience research, but manual implementation of these methods can limit throughput. We developed...
Depression is a leading concern for public health, however, the available treatments are insufficient for many patients. Ketamine is a promising yet enigmatic...
The availability of both visual and haptic information for a target object significantly improves reach-to-grasp actions, demonstrating that the nervous system...
Serotonin is a chemical that can be found in many parts of our body, including the brain. People have described it as a happiness chemical, as it is strongly...
We have taken a systems genetics look at sleep to peel back the many layers regulating sleep. Using this approach, we could connect specific DNA variations to...
The claustrum is a mysterious brain structure with vast connections, whose anatomy has limited investigation. We found a new approach for studying claustral...
Neuromorphic computers take inspiration from the brain to achieve enhanced efficiency. We describe the first full-scale simulation of a patch of cerebral...
Our study shows that the brain and its resident immune cells can acquire an immunological memory enabling the cells to either enhance or suppress their...
Semiaquatic fur seals have little or no REM sleep when in water for 2 weeks. Upon coming back to the land-life they return to have normally about 80 min of REM...
Microorganisms inhabiting our gut degrade certain nutrients into molecules capable of activating brain-resident immune cells to control inflammation. This...
